The Official Journal of the Turkish Society Of Clinical Microbiology and Infectious Diseases (KLİMİK)

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March 2025, Volume 7, Issue 1

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Review Article

Fungal β-Glucans: Biological Properties, Immunomodulatory Effects, Diagnostic and Therapeutic Applications

Fatemeh Amirinia and others

β-glucans area part of the fungal cell wall structure, mainly considered a potential therapeutic and diagnostic tool for invasive fungal infections (IFIs) (1). Several  studies have been conducted about their effects on health. They have been reported to reduce blood glucose and have a strong inhibitory effect on lipid peroxidation as a regulator of blood [...] Read More

Original Article

Healthcare-Associated Infection Rates in Türkiye (2014-2023): A Systematic Review and Meta-Analysis

Bahar Madran and others

Healthcare-associated infections (HAIs) are accepted as one of the most important challenges in hospital settings. They cause extended lengths of stay -at the hospital, threatening patient safety, increasing the rate of morbidity and mortality, raising the workforce of healthcare workers and accelerating antimicrobial resistance. According to the World Health Organization (WHO), [...] Read More

Determination of the Viremia and Genotype Distribution of the Hepatitis C Virus and the Seroprevalence of HIV Co-Infection

Fatih Mehmet Akıllı and others

Hepatitis C virus (HCV) is an enveloped, single-stranded, positive polarity RNA virus from the Flaviviridae family. It is part of the Hepacivirus genus, wrapped in a lipid bilayer containing two viral glycoproteins (E1 and E2). HCV infection is a major public health problem that can lead to complications such as cirrhosis and liver cancer. Approximately 85% of people [...] Read More

Rapid Detection of Pathogens and Resistance Genes Grown in Blood Cultures with Two Multiplex Tandem Real-Time PCR Kits

Barış Gülhan and others

Rapid diagnosis of pathogens grown in blood cultures reduces mortality and morbidity as appropriate treatment is started early. It notably reduces hospital costs because of less need for intensive care and earlier patient discharge. Although rapid identification and antibiogram of pathogens can be made with automated blood [...] Read More

An Analysis of Bacterial Infection Distribution in the Elderly, and Their Clinical and Laboratory Profiles: Aging and Bacterial Infection

Hanife Nur Karakoç-Parlayan and others

The demographic shift with an aging population worldwide has highlighted the unique healthcare challenges the elderly face. According to the Turkish Statistical Institute data, the population aged 65 and over reached 8,722,806 in 2023, accounting for 10.2% of the total population. Population projections indicate that the proportion of the elderly population is expected to reach 12.9% in 2030 [...] Read More

Predictors for Publication of Specialty Theses in the Field of Infectious Diseases and Clinical Microbiology

Pelin İrkören and others

The residency program of infectious diseases and clinical microbiology (IDCM) in Türkiye was started in 1983 by adopting the name IDCM. The IDCM program in Türkiye is a five-year program, including related clinical rotations. Presenting a thesis at the end of this program is mandatory. The first specialty thesis in the field of IDCM was [...] Read More

Analysis of Prosthetic Joint Infections, Risk Factors for Treatment Failure and Effect of Teicoplanin in Treatment: A Single-Center, Retrospective, Observational Study

Aybegüm Özşahin and others

With the prolongation of life expectancy and the developments in orthopedic surgery, noteworthy progress has been made in prosthetic joint surgery in recent years. Joint replacement provides pain relief, improves quality of life, and gives independence to individuals. Along with the advances in prosthetic surgery, prosthetic joint infection (PJI) is still the most feared complication of the procedure. Read More

Frequency and Genotype Diversity of Human Pegiviruses (HPgV) in People Infected with Human Immunodeficiency Virus (HIV)

Ebru Yücebağ-Duranay and others

Human pegiviruses (HPgV-1 and HPgV-2) are enveloped, single-stranded positive-sense RNA viruses belonging to the Pegivirus genus in the Flaviviridae family. HPgV has a genome of 8.9-11.3 kb, and the virion size is estimated at around 50-100 nm. Seven genotypes of HPgV-1 differ geographically. Two subtypes of genotype (GT) 2, which is common in Europe [...] Read More

Case Report

Candida Meningitis Accompanied by Upper Gastrointestinal Tract Candidiasis in an Immunocompromised Host

Derya Kormaz and others

Central nervous system (CNS) infections can develop due to bacteria, viruses, and fungi. The most common cause is bacteria. Although fungal meningitis is rare, there has been an increase in the number of cases in recent years. In the vast majority of CNS candidiasis, the primary site of infection is the lungs or skin, followed by direct or hematogenous [...] Read More

A Rare Agent in Blood: Rothia kristinae

Oğuz Usta and others

Rothia kristinae is a Gram-positive, non-motile facultative anaerobic coccus, a member of the Micrococcaceae family, first described in 1974 by Kloos and colleagues. Nomenclature revisited by Nouioui I. and colleagues in 2018, resulting in its reclassification as Rothia spp. (formerly classified as Kocuria kristinae). Read More

Letter to the Editor

The Diabetic Foot Wounds and Infections: Turkish Consensus Report, 2024

Ayten Kadanalı and others

The prevalence of diabetes continues to increase both in our country and in the world. The International Diabetes Federation estimated that as of 2021, 537 million adults in the world were living with diabetes. In Türkiye, this number is over 9 million. This situation leads [...] Read More

Declaration of Helsinki: Comparison of the 2024 Version and the 2013 Version

Barış Bulut and others

Dear Editor, since it was first published at the 18th meeting of the World Medical Association (WMA) in 1964, the Declaration of Helsinki (DoH) has been revised nine times, including the 2013 revision, and has been updated to the latest version with the 2024 revision. For this revision, [...] Read More

Cover

Imhotep, Egyptian Polymath and Physician (fl. c. 2625 BC)

Imhotep, who lived around 2650-2600 BC, was an accomplished Egyptian polymath. He served the Third Dynasty’s King Djoser as chancellor and high priest of the sun god, Ra, at Heliopolis. Regarded by some as the first architect, engineer, and physician in recorded history, Imhotep was one of the rare commoners to achieve divine status posthumously. […] Read More